in spite of:
不顾,不管；尽管
一般说来，in spite of的语气较强，使用范围也较广
例句与用法:
1. He continued with his plan to build a flying machine, in spite of the mockery of his friends.
他不顾朋友们的反对,继续他建造飞行器的计划.
2. In spite of the bad weather, we went fishing.
我们不顾恶劣的天气而去钓鱼.
3. I went shopping in spite of the rain.
尽管下雨,我还是出去买东西了.
4. We held on for two days in spite of the violent attacks of the enemy.
尽管敌人进行了猛烈攻击, 我们坚守了两天之久.
5. I know whatever you try, you'll win out in spite of early difficulties.
我知道你无论做什么,不管最初多么困难,最终都会成功.
6. In spite of my efforts at persuasion, he wouldn't agree.
尽管我努力劝说,他还是不同意.
7. He persisted in carrying on the experiment in spite of all kinds of setbacks.
尽管遇到很多挫折, 他仍坚持做实验.
8. He failed to lift the rock in spite of all his exertions.
他虽竭尽全力,但仍然未能将那石头搬起来.
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